Augmentin 375 mg (Amoxicillin 250 mg + Clavulanic Acid 125 mg)

What Is Augmentin 375 mg?

Augmentin 375 mg is a combination antibiotic containing 250 mg of amoxicillin and 125 mg of clavulanic acid. Amoxicillin belongs to the penicillin group of antibiotics, while clavulanic acid helps protect amoxicillin from certain bacterial enzymes. This combination is prescribed for infections caused by susceptible bacteria, including selected respiratory, urinary tract, ear, sinus and skin infections. Its suitability depends on the type of infection, bacterial susceptibility and the patient’s medical history.

How Does Augmentin 375 mg Work?

Augmentin 375 mg works through two active ingredients. Amoxicillin interferes with bacterial cell wall formation, eventually killing susceptible bacteria.

Clavulanic acid blocks certain beta-lactamase enzymes that some bacteria produce to destroy amoxicillin. Together, these ingredients extend the antibiotic’s activity against certain bacteria.

However, Augmentin is not effective against every bacterial infection.

How to Take Augmentin 375 mg

Take Augmentin 375 mg exactly as prescribed by your healthcare professional. The dosage and treatment duration depend on the infection and individual medical requirements.

General administration instructions include:

• Take the tablet with a meal to reduce stomach discomfort.

• Swallow the tablet with water.

• Follow the prescribed dosing schedule.

• Complete the prescribed treatment course unless your doctor advises otherwise.

• Never take two doses together to compensate for a missed dose.

Do not change your dosage without medical advice.

For additional administration information, visit the NHS guide to co-amoxiclav.

Side Effects of Augmentin 375 mg

Like other antibiotics, Augmentin 375 mg may cause side effects, although not everyone experiences them.

Common side effects:

• Diarrhoea

• Nausea and vomiting

• Stomach discomfort

• Oral or vaginal thrush

• Skin rash

Serious reactions can include severe allergic reactions, liver problems and severe antibiotic-associated diarrhoea.

Seek immediate medical assistance if you experience breathing difficulties, facial swelling or a severe skin reaction. Contact a doctor promptly for persistent severe diarrhoea or yellowing of the skin or eyes.

Warnings & Interactions

Avoid Augmentin 375 mg if you have a known serious allergy to penicillin antibiotics. Inform your doctor about previous antibiotic-related liver problems.

Augmentin may interact with certain medications, including:

• Warfarin

• Methotrexate

• Probenecid

• Allopurinol

Tell your healthcare professional about all prescription medicines, supplements and herbal products you use.

For detailed prescribing information, consult DailyMed: Amoxicillin and Clavulanate Potassium.

Safety Advice

🫀 Liver Disease

Patients with liver disease require medical assessment before taking Augmentin 375 mg. People who previously experienced Augmentin-associated liver dysfunction or jaundice should not take it.

🫘 Kidney Impairment

Patients with kidney problems may require dosage adjustments. Your doctor may assess kidney function before prescribing this antibiotic.

🤰 Pregnancy & Breastfeeding

Augmentin may be prescribed during pregnancy when medically necessary. It is also generally compatible with breastfeeding, although medical advice is recommended. Monitor breastfed infants for diarrhoea, thrush or unusual symptoms.

🍷 Alcohol & Things to Avoid

There is no specific alcohol prohibition for co-amoxiclav, but avoiding excessive alcohol is sensible, particularly if you feel unwell.

Avoid unnecessary antibiotic use and never share prescribed antibiotics with others.

Storage

Store Augmentin 375 mg tablets according to the product packaging, generally at or below 25°C. Protect tablets from moisture and excessive heat.

Keep the medication in its original packaging, away from children. Do not use expired tablets.

Frequently Asked Questions

What is Augmentin 375 mg used for?

Augmentin 375 mg treats certain bacterial infections, including selected respiratory, sinus, ear, urinary tract and skin infections.

Can I take Augmentin 375 mg without food?

Taking Augmentin with a meal is generally recommended to reduce gastrointestinal side effects.

How long does Augmentin 375 mg take to work?

Treatment begins acting against susceptible bacteria after administration. Symptom improvement varies depending on the infection and individual response.

Is Augmentin 375 mg safe during pregnancy?

It may be prescribed during pregnancy when a healthcare professional determines that treatment is appropriate.

Can Augmentin 375 mg treat viral infections?

No. Augmentin is an antibacterial medicine and does not treat viral infections such as influenza or the common cold.